Phenotypic and functional T-cell aging in Rhesus Macaques (Macaca mulatta) : differential behavior of CD4 and CD8 subsets Running title: Aging and different programs of CD8 and CD4 T-cells

OHSU Vaccine and Gene Therapy Institute and the Division of Pathobiology, Oregon National Primate Research Center, Beaverton, OR 97006 and the Department of Molecular Microbiology and Immunology of the Oregon Health & Science University, Portland, OR 97201 Note: Supported by the USPHS awards NIA AG 21384 (J. N-Z.) and NCRR P51 RR 00163 (Core National Primate Center Support Grant) from the National Institutes of Health 1 – to whom correspondence should be addressed at the Vaccine and Gene Therapy Institute, 505 NW 185 Ave. Beaverton, OR 97006, e-mail : [email protected]